Ivermectin B1a
Cat. No.：YN250398
| 产品名称: | Ivermectin B1a |
| CAS No.: | 71827-03-7 |
| Chemical Name: | 5-O-demethyl-22,23-dihydro-avermectin A1a |
| Synonyms: | |
| 分子量: | 875.09 |
| 分子式: | C₄₈H₇₄O₁₄ |
| SMILES: | C/C([C@H]([C@H](/C=C/C=C1CO[C@]([H])([C@@H](C(C)=C[C@]2(C3=O)[H])O)[C@@]\12O)C)O[C@]4(C[C@@H]([C@H]([C@@H](O4)C)O[C@@]5(O[C@H]([C@@H]([C@H](C5)OC)O)C)[H])OC)[H])=C\C[C@@]6(C[C@@]([H])(C[C@@]7(O6)CC[C@@H]([C@]([H])(O7)[C@@H](C)CC)C)O3)[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ivermectin B1a 是 Avermectin B1a (HY-15308) 的衍生物，是 Ivermectin (HY-15310) 的主要成分。Ivermectin (MK-933) 是一种广谱抗寄生虫剂。Ivermectin 是应用于抗 SARS-CoV-2/COVID-19 的候选药物。 |
| IC50和靶点: | |
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Campbell, W.C., Fisher, M.H., Stapley, E.O., et al.Ivermectin: A potent new antiparasitic agentScience221(4613),823-828(1983)
Wolsetnholme, A.J., and Rogers, A.T.Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelminticsParasitology131(Suppl),S85-S95(2005)
Arena, J.P., Liu, K.K., Paress, P.S., et al.The mechanism of action of avermectins in Caenorhabditis elegans: Correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activityJ. Parasitol.81(2),286-294(1995)
Caly, L., Druce, J.D., Catton, M.G., et al.The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitroAntiviral Res.178:104787,(2020)
