Borrelidin
Cat. No.：YN251707
| 产品名称: | Borrelidin |
| CAS No.: | 7184-60-3 |
| Chemical Name: | (1R)-2R-[7-cyano-8R,16S-dihydroxy-9S,11R,13S,15S-tetramethyl-18-oxooxacyclooctadeca-4E,6Z-dien-2S-yl]-cyclopentanecarboxylic acid |
| Synonyms: | Treponemycin |
| 分子量: | 489.64 |
| 分子式: | C₂₈H₄₃NO₆ |
| SMILES: | O=C([C@H]1[C@H]([C@H](C/C=C/C=C(C#N)\[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)C2)OC2=O)CCC1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Borrelidin (Treponemycin) 是细菌和真核threonyl-tRNA 合成酶的抑制剂，是Streptomyces rochei中分离的含氮大环内酯类抗生素。Borrelidin (Treponemycin) 是一种出芽酵母Cdc28/Cln2抑制剂，其作用的IC50值为 24 μM。Borrelidin (Treponemycin) 是一种强效的血管生成抑制剂，其IC50值为 0.8 nM，可诱导血管形成细胞凋亡。Borrelidin (Treponemycin) 具有较强的抗疟活 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Wakabayashi, T., Kageyama, R., Naruse, N., et al.Borrelidin is an angiogenesis inhibitor; Disruption of angiogenic capillary vessels in a rat aorta matrix culture modelJ. Antibiot. (Tokyo)50(8),671-676(1997)
Kawamura, T., Liu, D., Towle, M.J., et al.Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: Threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cellsJ. Antibiot. (Tokyo)56(8),709-715(2003)
Woolard, J., Vousden, W., Moss, S.J., et al.Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoformsChem. Sci.2011(2),273-278(2011)
Paetz, W., and Nass, G.Biochemical and immunological characterization of threonyl-tRNA synthetase of two borrelidin-resistant mutants of Escherichia coli K12Eur. J. Biochem.35(2),331-337(1973)
Otoguro, K., Ui, H., Ishiyama, A., et al.In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of PlasmodiaJ. Antibiot. (Tokyo)56(8),727-729(2003)
Tsuchiya, E., Yukawa, M., Miyakawa, T., et al.Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiaeJ. Antibiot. (Tokyo)54(1),84-90(2001)
