N-Desethyl amodiaquine dihydrochloride
Cat. No.：YN250415
CAS No. ：79049-30-2
| 产品名称: | N-Desethyl amodiaquine dihydrochloride |
| CAS No.: | 79049-30-2 |
| Chemical Name: | 4-[(7-chloro-4-quinolinyl)amino]-2-[(ethylamino)methyl]-phenol, dihydrochloride |
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| 分子量: | 400.73 |
| 分子式: | C₁₈H₂₀Cl₃N₃O |
| SMILES: | OC1=CC=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1CNCC.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | N-Desethyl amodiaquine dihydrochloride 是 Amodiaquine 的主要生物活性代谢产物。N-Desethyl amodiaquine dihydrochloride 是一种抗寄生虫剂，对菌株 V1/S 和 3D7 的 IC50值分别为 97 nM 和 25 nM。 |
| IC50和靶点: | |
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Li, X.Q., Björkman, A., Andersson, T.B., et al.Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: A new high affinity and turnover enzyme-specific probe substrateJ. Pharmacol. Exp. Ther.300(2),399-407(2002)
Mariga, S.T., Gil, J.P., Sisowath, C., et al.Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitroAntimicrob. Agents Chemother.48(11),4089-4096(2004)
