Cipargamin
Cat. No.：YN250587
CAS No. ：1193314-23-6
| 产品名称: | Cipargamin |
| CAS No.: | 1193314-23-6 |
| Chemical Name: | (1′R,3′S)-5,7′-dichloro-6′-fluoro-2′,3′,4′,9′-tetrahydro-3′-methyl-spiro[3H-indole-3,1′-[1H]pyrido[3,4-b]indol]-2(1H)-one |
| Synonyms: | NITD609; KAE609 |
| 分子量: | 390.24 |
| 分子式: | C₁₉H₁₄Cl₂FN₃O |
| SMILES: | FC1=C(Cl)C=C(NC2=C3C[C@H](C)N[C@@]2(C4=C(C=CC(Cl)=C4)N5)C5=O)C3=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cipargamin (NITD609) 是一种有效的抗疟疾药，对恶性疟原虫的IC50值约为 1 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Rosling, J.E.O., Ridgway, M.C., Summers, R.L., et al.Biochemical characterization and chemical inhibition of PfATP4-associated Na+-ATPase activity in Plasmodium falciparum membranesJ. Biol. Chem.293(34),13327-13337(2018)
van Pelt-Koops, J.C., Pett, H.E., Graumans, W., et al.The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vectorAntimicrob. Agents Chemother.56(7),3544-3548(2012)
Rottmann, M., McNamara, C., Yeung, B.K.S., et al.Spiroindolones, a potent compound class for the treatment of malariaScience329(5996),1175-1180(2010)
