RRx-001
Cat. No.：YN250663
CAS No. ：925206-65-1
| 产品名称: | RRx-001 |
| CAS No.: | 925206-65-1 |
| Chemical Name: | 2-bromo-1-(3,3-dinitro-1-azetidinyl)-ethanone |
| Synonyms: | RRx 001,RRx001 |
| 分子量: | 268.02 |
| 分子式: | C₅H₆BrN₃O₅ |
| SMILES: | BrCC(N1CC([N+]([O-])=O)([N+]([O-])=O)C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RRx-001 是一种低氧选择性的表观遗传因子，被用作放射或化疗敏感剂，能诱发凋亡，克服骨髓瘤的耐药性。RRx-001 具有有效的抗癌活性且毒性极低。RRx-001是一个免疫检查点的抑制剂，可下调CD47和SIRP-α。RRx-001是G6PD的有效抑制剂，具有较强的抗疟活性。 |
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Ning, S., Bednarski, M., Oronsky, B., et al.Dinitroazetidines are a novel class of anticancer agents and hypoxia-activated radiation sensitizers developed from highly energetic materialsCancer Res.72(10),2600-2608(2012)
Fens, M.H., Cabrales, P., Scicinski, J., et al.Targeting tumor hypoxia with the epigenetic anticancer agent, RRx-001: A superagonist of nitric oxide generationMed. Oncol.33(8),85(2016)
Yalcin, O., Oronsky, B., Carvalho, L.J.M., et al.From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malariaMalar. J.14,218(2015)
