Artefenomel
Cat. No.：YN250681
CAS No. ：1029939-86-3
| 产品名称: | Artefenomel |
| CAS No.: | 1029939-86-3 |
| Chemical Name: | 4-[2-(4-cis-dispiro[cyclohexane-1,3′-[1,2,4]trioxolane-5′,2′′-tricyclo[3.3.1.13,7]decan]-4-ylphenoxy)ethyl]-morpholine |
| Synonyms: | OZ439 |
| 分子量: | 469.61 |
| 分子式: | C₂₈H₃₉NO₅ |
| SMILES: | [H][C@@]1(C[C@H](C2)C3)C4([C@@]3([H])C[C@H]2C1)O[C@]5(OO4)CC[C@H](CC5)C6=CC=C(C=C6)OCCN7CCOCC7 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Artefenomel (OZ439) 是一种合成的含有青蒿素药效团的抗疟疾药物。Artefenomel (OZ439) 是一种长效青蒿素相关化合物。 |
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Yang, T., Xie, S.C., Cao, P., et al.Comparison of the exposure time dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wild-type and mutant Plasmodium falciparum strainsAntimicrob. Agents Chemother.60(8),4501-4510(2016)
Giannangelo, C., Stingelin, L., Yang, T., et al.Parasite-mediated degradation of synthetic ozonide antimalarials impacts in vitro antimalarial activityAntimicrob. Agents Chemother.62(3),e01566-e01617(2018)
Kim, H.S., Hammill, J.T., and Guy, R.K.Seeking the elusive long-acting ozonide: Discovery of artefenomel (OZ439)J. Med. Chem.60(7),2651-2653(2017)
