Proguanil
Cat. No.：YN251137
CAS No. ：500-92-5
| 产品名称: | Proguanil |
| CAS No.: | 500-92-5 |
| Chemical Name: | N-(4-chlorophenyl)-N′-(1-methylethyl)-imidodicarbonimidic diamide |
| Synonyms: | 氯胍 |
| 分子量: | 253.73 |
| 分子式: | C₁₁H₁₆ClN₅ |
| SMILES: | N=C(NC1=CC=C(Cl)C=C1)NC(NC(C)C)=N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Proguanil 是一种抗疟前药，被代谢为活性代谢物环鸟苷 (HY-12784)。Proguanil 是一种二氢叶酸还原酶 (DHFR) 抑制剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Birkett, D.J., Rees, D., Anderson, T., et al.In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylaseBr. J. Clin. Pharmacol.37(5),413-420(1994)
Thapar, M.M., Gupta, S., Spindler, C., et al.Pharmacodynamic interactions among atovaquone, proguanil and cycloguanil against Plasmodium falciparum in vitroTrans. R. Soc. Trop. Med. Hyg.97(3),331-337(2003)
Black, R.H., and Ray, A.P.Experimental studies of the potentiation of proguanil and pyrimethamine by dapsone using Plasmodium berghei in white miceAnn. Trop. Med. Parasitol.71(2),131-139(1977)
