3,5-Diiodothyropropionic acid
Cat. No.：YN480870
CAS No. ：1158-10-7
| 产品名称: | 3,5-Diiodothyropropionic acid |
| CAS No.: | 1158-10-7 |
| Chemical Name: | 4-(4-hydroxyphenoxy)-3,5-diiodo-benzenepropanoic acid |
| Synonyms: | Ditpa cpd,C082182,3,5-二碘甲腺丙酸 |
| 分子量: | 510.06 |
| 分子式: | C₁₅H₁₂I₂O₄ |
| SMILES: | O=C(O)CCC1=CC(I)=C(OC2=CC=C(O)C=C2)C(I)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 3,5-Diiodothyropropionic acid 是甲状腺激素类似物，可诱导 α-肌球蛋白重链 mRNA 表达，与甲状腺激素受体 (thyroid hormone receptors (TR)) 结合，对 TRα1 和 TRβ1 的 Ka值分别为 2.40 和 4.06 M-1。 |
| IC50和靶点: | |
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Pennock, G.D., Raya, T.E., Bahl, J.J., et al.Cardiac effects of 3,5-diiodothyropropionic acid, a thyroid hormone analog with inotropic selectivityJ. Pharmacol. Exp. Ther.263(1),163-169(1992)
Litwin, S.E., Zhang, D., Roberge, P., et al.DITPA prevents the blunted contraction-frequency relationship in myocytes from infarcted heartsAm. J. Physiol. Heart Circ. Physiol.278(3),H862-H870(2000)
Wang, X., Zheng, W., Christensen, L.P., et al.DITPA stimulates bFGF, VEGF, angiopoietin, and Tie-2 and facilitates coronary arteriolar growthAm. J. Physiol. Heart Circ. Physiol.284(2),H613-H618(2003)
Zheng, W., Weiss, R.M., Wang, X., et al.DITPA stimulates arteriolar growth and modifies myocardial postinfarction remodelingAm. J. Physiol. Heart Circ. Physiol.286(5),H1994-H2000(2004)
