Lesinurad
Cat. No.：YN360528
CAS No. ：878672-00-5
| 产品名称: | Lesinurad |
| CAS No.: | 878672-00-5 |
| Chemical Name: | 2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic acid |
| Synonyms: | 雷西那德; RDEA594 |
| 分子量: | 404.28 |
| 分子式: | C₁₇H₁₄BrN₃O₂S |
| SMILES: | BrC1=NN=C(SCC(O)=O)N1C2=C3C(C=CC=C3)=C(C4CC4)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lesinurad 是一种URAT1和OAT抑制剂，用作肾转运蛋白OAT1 和OAT3 的底物，Km值分别为 0.85 和 2 μM。 |
| IC50和靶点: | |
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Tan, P.K., Ostertag, T.M., and Miner, J.N.Mechanism of high affinity inhibition of the human urate transporter URAT1Sci. Rep.6:34995,(2016)
Wu, T., Chen, J., Dong, S., et al.Identification and characterization of a potent and selective inhibitor of human urate transporter 1Pharmacol. Rep.,(2017)
