Verteporfin
Cat. No.：YN450136
CAS No. ：129497-78-5
规格
价格(RMB)
库存
| 产品名称: | Verteporfin |
| CAS No.: | 129497-78-5 |
| Chemical Name: | (4R,4aS)-rel-18-ethenyl-4,4a-dihydro-3,4-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid, monomethyl ester |
| Synonyms: | 维替泊芬; CL 318952 |
| 分子量: | 718.79 |
| 分子式: | C₄₁H₄₂N₄O₈ |
| SMILES: | C[C@]1(/C2=C/C(N3)=C4C)C(C(/C=C(C(C)=C/5C=C)\NC5=C/C6=N/C(C(CCC(OC)=O)=C6C)=C\C3=C4CCC(O)=O)=N2)=CC=C(C(OC)=O)[C@H]1C(OC)=O.C[C@]7(/C8=C/C(N9)=C%10C)C(C(/C=C(C(C)=C/%11C=C)\NC%11=C/C%12=N/C(C(CCC(O)=O)=C%12C)=C\C9=C%10CCC(OC)=O)=N8)=CC=C(C(OC)=O)[C@H]7C(O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Verteporfin (CL 318952) 是一种用于光动力疗法的光敏剂，用于消除与年龄相关的黄斑变性等疾病相关的眼内异常血管。 Verteporfin 是一种YAP抑制剂，可破坏 YAP-TEAD 相互作用。Verteporfin 可以诱导细胞凋亡 (apoptosis)。Verteporfin 是一种自噬 (autophagy) 抑制剂，通过抑制自噬小体形成，在早期阻断自噬。 |
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Schmidt-Erfurth, U., and Hasan, T.Mechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degenerationSurv. Ophthalmol.45(3),195-214(2000)
Donohue, E., Balgi, A.D., Komatsu, M., et al.Induction of covalently crosslinked p62 oligomers with reduced binding to polyubiquitinated proteins by the autophagy inhibitor verteporfinPLoS One9(12),1-30(2014)
