GSK8612
Cat. No.：YN410017
CAS No. ：2361659-62-1
| 产品名称: | GSK8612 |
| CAS No.: | 2361659-62-1 |
| Chemical Name: | 4-[[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]amino]-4-pyrimidinyl]amino]methyl]-benzenesulfonamide |
| Synonyms: | GSK8612,GSK-8612，GSK 8612 |
| 分子量: | 520.33 |
| 分子式: | C₁₇H₁₇BrF₃N₇O₂S |
| SMILES: | NS(C1=CC=C(CNC2=C(Br)C=NC(NC3=CN(CC(F)(F)F)N=C3C)=N2)C=C1)(=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK8612 是具有高度选择性的，TBK1的强效抑制剂，对重组TBK1 的pIC50值为 6.8。 |
| IC50和靶点: | [{name:"TBK1:6.8 (pIC50)"}] |
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| Solvent & Solubility: |
Thomson, D.W., Poeckel, D., Zinn, N., et al.Discovery of GSK8612, a highly selective and potent TBK1 inhibitorMed. Chem. Lett.10(5),780-785(2019)
Jiang, Y., Chen, S., Li, Q., et al.TANK-binding kinase 1 (TBK1) serves as a potential target for hepatocellular carcinoma by enhancing tumor immune infiltrationFront. Immunol.12,612139(2021)
