SC-514
Cat. No.：YN410056
CAS No. ：354812-17-2
规格
价格(RMB)
库存
| 产品名称: | SC-514 |
| CAS No.: | 354812-17-2 |
| Chemical Name: | 4-amino-[2,3'-bithiophene]-5-carboxamide |
| Synonyms: | GK 01140 |
| 分子量: | 224.30 |
| 分子式: | C₉H₈N₂OS₂ |
| SMILES: | O=C(C1=C(N)C=C(C2=CSC=C2)S1)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SC-514 是一种选择性IKK-2抑制剂 (IC50=11.2 μM)，不抑制其他 IKK 亚型或其他丝氨酸-苏氨酸和酪氨酸激酶。 |
| IC50和靶点: | [{name:"IKK-2:11.2 μM (IC50)"},{name: "CDK2/A:61 μM (IC50)"},{name: "AUR2:71 μM (IC50)"},{name: "PRAK:75 μM (IC50)"},{name: "MSK:123 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Kishore, N., Sommers, C., Mathialagan, S., et al.A selective IKK-2 inhibitor blocks NF- kB-dependent gene expression in interleukin-1β-stimulated synovial fibroblastsJ. Biol. Chem.278(35),32861-32871(2003)
Baxter, A., Brough, S., Cooper, A., et al.Hit-to-lead studies: The discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitorsBioorg. Med. Chem. Lett.14(11),2817-2822(2004)
Gomez, A.B., MacKenzie, C., Paul, A., et al.Selective inhibition of inhibitory kappa B kinase-β abrogates induction of nitric oxide synthase in lipopolysaccharide-stimulated rat aortic smooth muscle cellsBr. J. Pharmacol.146(2),217-225(2005)
Phulwani, N.K., Esen, N., Syed, M.M., et al.TLR2 expression in astrocytes is induced by TNF-α-and NF-kB-dependent pathwaysJ. Immunol.181(6),3841-3849(2008)
