IT-901
Cat. No.：YN410166
CAS No. ：1584121-99-2
| 产品名称: | IT-901 |
| CAS No.: | 1584121-99-2 |
| Chemical Name: | 5-[(2,4-dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione |
| Synonyms: | IT-901;5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione;IT 901;5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione;IT901;AMY16809;5-[(2,4-dimethoxynaphthalen-1-yl)methylidene]-2-sulf |
| 分子量: | 342.4 |
| 分子式: | C17H14N2O4S |
| SMILES: | S=C(N1)NC(/C(C1=O)=C\C2=C(OC)C=C(OC)C3=C2C=CC=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IT-901 是一种具有口服活性且有效的NF-κB亚基c-Rel抑制剂，对NF-κB和c-Rel与 DNA 结合的IC50分别为 0.1 µM，3 μM。IT-901 是一种具有生物活性的萘硫代巴比妥酸酯衍生物，具有用于人类淋巴瘤和改善移植物抗宿主病 (GVHD) 的潜力。 |
| IC50和靶点: | [{name:"c-Rel:3 μM (IC50)"},{name: "NF-κB:0.1 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Shono, Y., Tuckett, A.Z., Liou, H.-C., et al.Characterization of a c-Rel inhibitor that mediates anticancer properties in hematologic malignancies by blocking NF-κB-controlled oxidative stress responsesCancer Res.76(2),377-389(2016)
Vaisitti, T., Gaudino, F., Ouk, S., et al.Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitorHaematologica102(11),1878-1889(2017)
