nor-NOHA acetate
Cat. No.：YN330125
| 产品名称: | nor-NOHA acetate |
| CAS No.: | 1140844-63-8 |
| Chemical Name: | 2S-amino-4-[[(hydroxyamino)iminomethyl]amino]-butanoic acid, diacetate |
| Synonyms: | Nω-Hydroxy-nor-L-arginine acetate |
| 分子量: | 296.28 |
| 分子式: | C₉H₂₀N₄O₇ |
| SMILES: | O=C(O)[C@@H](N)CCNC(NO)=N.CC(O)=O.CC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) 是一种特异性、可逆的arginase抑制剂，在缺氧条件下，可诱导 ARG2 表达细胞的凋亡。具有抗白血病的作用，同时在内皮功能障碍、免疫抑制及代谢中有效。 |
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Custot, J., Moali, C., Brollo, M., et al.A new α-amino acid Nw-hydroxy-nor-L-arginine: A highly-affinity inhibitor of arginase well adapted to bind to its manganese clusterJ. Am. Chem. Soc.119(17),4086-4087(1997)
Tenu, J.P., Lepoivre, M., Moali, C., et al.Effects of the new arginase inhibitor Nw-hydroxy-nor-L-arginine on NO synthase activity in murine macrophagesNitric Oxide3(6),427-438(1999)
Dijols, S., Perollier, C., Lefevre-Groboillot, D., et al.Oxidation of Nw-hydroxyarginine analogues by NO-synthase: The simple, non amino acid N-butyl N'-hydroxyguanidine is almost as efficient an NO precursor as Nw-hydroxyarginineJ. Med. Chem.44(20),3199-3202(2001)
Moali, C., Brollo, M., Custot, J., et al.Recognition of α-amino acids bearing various C=NOH functions by nitric oxide synthase and arginase involves very different strctural determinantsBiochemistry39(28),8208-8218(2000)
