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Tropicamide

Cat. No.:YN321450

  • CAS No. :1508-75-4

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    • 产品名称: Tropicamide
      CAS No.: 1508-75-4
      Chemical Name: N-ethyl-α-(hydroxymethyl)-N-(4-pyridinylmethyl)-benzeneacetamide
      Synonyms:托吡卡胺; Ro 1-7683
      分子量:284.35
      分子式:C₁₇H₂₀N₂O₂
      SMILES:O=C(N(CC)CC1=CC=NC=C1)C(C2=CC=CC=C2)CO
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Tropicamide (Ro 1-7683) 是一种选择性的M4毒蕈碱乙酰胆碱受体拮抗剂。Tropicamide 作为滴眼剂使用时,会产生短效散瞳(瞳孔扩张)和睫状肌麻痹。
      IC50和靶点:
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    • Lazareno, S., Buckley, N.J., and Roberts, F.F.Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cellMol. Pharmacol.38(6),805-815(1990)

      Liao, C.F., Themmen, A.P.N., Joho, R., et al.Molecular cloning and expression of a fifth muscarinic acetylcholine receptorJ. Biol. Chem.264(13),7328-7337(1989)

      Lazareno, S., and Birdsall, N.J.M.Pharmacological characterization of acetylcholine-stimulated [35S]-GTPγS binding mediated by human muscarinic m1-m4 receptors: Antagonist studiesBr. J. Pharmacol.109(4),1120-1127(1993)

      Hernández, M., Símonsen, U., Prieto, D., et al.Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureterBr. J. Pharmacol.110(4),1413-1420(1993)

      Smith, S.E.Dose-response relationships in tropicamide-induced mydriasis and cycloplegiaBr. J. Clin. Pharmacol.1(1),37-40(1974)

      Veeraragavan, S., Bui, N., Perkins, J.R., et al.The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamideBehav. Neurosci.125(5),783-790(2011)

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