Xaliproden hydrochloride
Cat. No.：YN320895
CAS No. ：90494-79-4
| 产品名称: | Xaliproden hydrochloride |
| CAS No.: | 90494-79-4 |
| Chemical Name: | 1,2,3,6-tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-pyridine, monohydrochloride |
| Synonyms: | SR57746A; SR57746 hydrochloride |
| 分子量: | 417.89 |
| 分子式: | C₂₄H₂₃ClF₃N |
| SMILES: | FC(C1=CC(C2=CCN(CCC3=CC=C4C=CC=CC4=C3)CC2)=CC=C1)(F)F.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Xaliproden hydrochloride (SR57746A) 是一种有效、选择性和具有口服活性的5-HT1A受体激动剂，对大鼠海马中的 5-HT1A特异性结合位点表现出高亲和力 (IC50=3 nM)。Xaliproden hydrochloride 也是一种选择性的多巴胺D2受体拮抗剂，具有中等亲和力 (IC50=0.1-1 μM)。Xaliproden hydrochloride 具有抗抑郁作用和抗焦虑作用，并且具有研究神经退行性疾病的潜力。 |
| IC50和靶点: | [{name:"5-HT1A Receptor:3 nM (IC50)"},{name: "D2 Receptor:0.1-1 μM (IC50)"}] |
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Bachy, A., Steinberg, R., Santucci, V., et al.Biochemical and electrophysiological properties of SR 57746A, a new, potent 5-HT1A receptor agonistFundam. Clin. Pharmacol.7(9),487-497(1993)
Pradines, A., Magazin, M., Schlitz, P., et al.Evidence for nerve growth factor-potentiating activities of the nonpeptidic compound SR 57746A in PC12 cellsJ. Neurochem.64(5),1954-1964(1995)
Fournier, J., Steinberg, R., Gauthier, T., et al.Protective effects of SR 57746A in central and peripheral models of neurodegenerative disorders in rodents and primatesNeuroscience55(3),629-641(1993)
Bourrié, B., Bribes, E., Esclangon, M., et al.The neuroprotective agent SR 57746A abrogates experimental autoimmune encephalomyelitis and impairs associated blood-brain barrier disruption: Implications for multiple sclerosis treatmentProc. Natl. Acad. Sci. USA96(22),12855-12859(1999)
