ER-819762
Cat. No.：YN322167
| 产品名称: | ER-819762 |
| CAS No.: | 1155773-15-1 |
| Chemical Name: | (10S)-1′-[(3,5-dimethylphenyl)methyl]-2-ethyl-5,10-dihydro-7,9-dimethoxy-10-methyl-spiro[1H-imidazo[1,5-b][2]benzazepine-1,4′-piperidin]-3(2H)-one |
| Synonyms: | ER819762 |
| 分子量: | 489.7 |
| 分子式: | C30H39N3O3 |
| SMILES: | O=C1N(CC)C2(CCN(CC3=CC(C)=CC(C)=C3)CC2)C4=C[C@H](C)C5=C(C=C(OC)C=C5OC)CN41 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ER-819762 是一种具有口服活性的、高选择性前列腺素 E2(PGE2)EP4受体拮抗剂，对人EP4受体的EC50为 70 nM。 ER-819762 可用于类风湿关节炎的研究。 |
| IC50和靶点: | [{name:"EP4:70 nM (IC50)"}] |
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| Solvent & Solubility: |
Chen, Q., Muramoto, K., Masaaki, N., et al.A novel antagonist of the prostaglandin E2 EP4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis modelsBr. J. Pharmacol.160(2),292-310(2010)
Boodhoo, N., Kamble, N., Kaufer, B.B., et al.Replication of Marek's disease virus is dependent on synthesis of de novo fatty acid and prostaglandin E2J. Virol.93(13),e00352-00319(2109)
