ICI 192605
Cat. No.：YN322171
| 产品名称: | ICI 192605 |
| CAS No.: | 117621-64-4 |
| Chemical Name: | (4Z)-rel-6-[(2R,4R,5S)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-4-hexenoic acid |
| Synonyms: | ICI 192605 ; ICI192605; ICI-192605 . |
| 分子量: | 402.9 |
| 分子式: | C22H23ClO5 |
| SMILES: | OC1=C(C=CC=C1)[C@H]2O[C@H](OC[C@H]2C/C=C\CCC(O)=O)C3=C(Cl)C=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ICI 192605 作为细胞信号前列腺素是一种有效的TXA2R(血栓素 A2 受体) 拮抗剂，ICI 192605 阻断 U-46619 诱导的豚鼠离体气管收缩。 |
| IC50和靶点: | |
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Brewster, A.G., Brown, G.R., Foubister, A.J., et al.The synthesis of a novel thromboxane receptor antagonist 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid ICI 192605Prostaglandins36(2),173-178(1988)
Dubuffet, T., Muller, O., Simonet, S.S., et al.Synthesis of new 3,4-disubstituted pyrrolidines as thromboxane A2/prostaglandin H2 (TP) receptor antagonistsBioorg. Med. Chem. Lett.6(4),349-352(1996)
Hausermann, L., and St-Louis, J.Thromboxane and isoprostane share the same prostanoid receptors to increase human placental tonePlacenta32(12),941-948(2011)
Hewitt, M.M., Adams, G., Jr., Mazzone, S.B., et al.Pharmacology of bradykinin-evoked coughing in guinea pigsJ. Pharmacol. Exp. Ther.357(3),620-628(2016)
Janssen, L.J., and Tazzeo, T.Involvement of TP and EP3 receptors in vasoconstrictor responses to isoprostanes in pulmonary vasculatureJ. Pharmacol. Exp. Ther.301(3),1060-1066(2002)
Pettipher, R., Hansel, T.T., and Armer, R.Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseasesNat. Rev. Drug Discov.6,313-325(2007)
