Palmitoyl serinol
Cat. No.：YN322213
| 产品名称: | Palmitoyl serinol |
| CAS No.: | 126127-31-9 |
| Chemical Name: | N-[2-hydroxy-1-(hydroxymethyl)ethyl]-hexadecanamide |
| Synonyms: | N-Palmitoyl serinol |
| 分子量: | 329.5 |
| 分子式: | C19H39NO3 |
| SMILES: | CCCCCCCCCCCCCCCC(NC(CO)CO)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Palmitoyl serinol (N-Palmitoyl serinol) 是内源性大麻素 N-棕榈酰乙醇胺(PEA) 的类似物。Palmitoyl serinol 改善正常和炎症皮肤的表皮渗透屏障。 |
| IC50和靶点: | |
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Ben-Shabat, S., Fride, E., Sheskin, T., et al.An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activityEur. J. Pharmacol.353(1),23-31(1998)
Dinh, T.P., Freund, T.F., and Piomelli, D.A role for monoglyceride lipase in 2-arachidonoylglycerol inactivationChem. Phys. Lipids121(1-2),149-158(2002)
Fowler, C.J., Jonsson, K.-O., and Tiger, G.Fatty acid amide hydrolase: Biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamideBiochem. Pharmacol.62(5),517-526(2001)
Cohen, L.J., Esterhazy, D., Kim, S.H., et al.Commensal bacteria make GPCR ligands that mimic human signalling moleculesNature549(7670),48-53(2017)
Shin, K., -O., Kim, S., B.D., P., et al.N-Palmitoyl serinol stimulates ceramide production through a CB1-dependent mechanism in in vitro model of skin inflammationInt. J. Mol. Sci.22(15),8302(2021)
Bieberich, E., Kawaguchi, T., and Yu, R.K.N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cellsJ. Biol. Chem.275(1),177-181(2000)
