mesylate
Cat. No.：YN322225
CAS No. ：1308278-67-2
规格
价格(RMB)
库存
| 产品名称: | mesylate |
| CAS No.: | 1308278-67-2 |
| Chemical Name: | N'-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-di(methyl-d3)-urea |
| Synonyms: | RGH-188-d |
| 分子量: | 433.5 |
| 分子式: | C21H26D6Cl2N4O |
| SMILES: | O=C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])N[C@H](CC1)CC[C@@H]1CCN(CC2)CCN2C3=C(Cl)C(Cl)=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cariprazine-d6是 Cariprazine 氘代物。Cariprazine 是一种抗精神病药，结合多巴胺D3,D2和5-HT1A的Ki分别为 0.085 nM，0.49 nM 和 2.6 nM。 |
| IC50和靶点: | [{name:"5-HT1A Receptor:2.6 nM (Ki)"},{name: "Dopamine D2 Receptor:0.49 nM (Ki)"},{name: "Dopamine D3 Receptor:0.085 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Mészáros, G.P., Agai-Csongor, E., and Kapás, M.Sensitive LC-MS/MS methods for the quantification of RGH-188 and its active metabolites, desmethyl- and didesmethyl-RGH-188 in human plasma and urineJ. Pharm. Biomed. Anal.48(2),388-397(2008)
Kiss, B., Horváth, A., Némethy, Z., et al.Cariprazine (RGH-188), a dopamine D3 receptor-preferring, D3/D2 dopamine receptor antagonist-partial agonist antipsychotic candidate: In vitro and neurochemical profileJ. Pharmacol. Exp. Ther.333(1),328-340(2010)
Gyertyán, I., Kiss, B., Sághy, K., et al.Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodentsNeurochem. Int.59(6),925-935(2011)
