PF-06737007
Cat. No.：YN380359
| 产品名称: | PF-06737007 |
| CAS No.: | 1863905-38-7 |
| Chemical Name: | |
| Synonyms: | 2-((3R,4S)-3-Fluoro-1-(2-(4-(trifluoromethoxy)phenyl)acetyl)piperidin-4-yloxy)-4-(2-hydroxy-2-methylpropoxy)benzamide;2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-4-(2-hydroxy-2-methylpropoxy)benzamide;TQR0432;BDBM5045782 |
| 分子量: | 528.49 |
| 分子式: | C25H28F4N2O6 |
| SMILES: | F[C@]1([H])C([H])([H])N(C(C([H])([H])C2C([H])=C([H])C(=C([H])C=2[H])OC(F)(F)F)=O)C([H])([H])C([H])([H])[C@@]1([H])OC1C([H])=C(C([H])=C([H])C=1C(N([H])[H])=O)OC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])O[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-06737007 是一种有效的pan-Trk抑制剂，抑制TrkA，TrkB和TrkC细胞，IC50分别为 7.7 nM，15 nM 和 3.9 nM。具有抗痛觉过敏作用。 |
| IC50和靶点: | [{name:"TrkA:7.7 nM (IC50, in cell-based assays)"},{name: "TrkB:15 nM (IC50, in cell-based assays)"},{name: "TrkC:3.9 nM (IC50, in cell-based assays)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
