CAY10444
Cat. No.：YN322453
CAS No. ：298186-80-8
规格
价格(RMB)
库存
| 产品名称: | CAY10444 |
| CAS No.: | 298186-80-8 |
| Chemical Name: | 2-undecyl-4R-thiazolidinecarboxylic acid |
| Synonyms: | BML-241 |
| 分子量: | 287.5 |
| 分子式: | C15H29NO2S |
| SMILES: | [H]N1C(CCCCCCCCCCC)SC[C@H]1C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CAY10444 (BML-241) 是一种sphingosine-1-phosphate 3 (S1P3)拮抗剂。CAY10444 在表达 S1P3 受体的 HeLa 细胞中抑制 37% S1P 诱导的 Ca2+增加。 |
| IC50和靶点: | |
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Koide, Y., Hasegawa, T., Takahashi, A., et al.Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationshipsJ. Med. Chem.45(21),4629-4638(2002)
Wang, M., Wu, H., Wang, R., et al.Inhibition of sphingosine 1-phosphate (S1P) receptor 1/2/3 ameliorates biological dysfunction in rheumatoid arthritis fibroblast-like synoviocyte MH7A cells through Gαi/Gαs rebalancingClin. Exp. Pharmacol. Physiol.48(8),1080-1089(2021)
Al Alam, N., and Kreydiyyeh, S.I.FTY720P inhibits hepatic Na+-K+ ATPase via S1PR2 and PGE2Biochem. Cell Biol.94(4),371-377(2016)
