Rivastigmine tartrate
Cat. No.：YN380039
CAS No. ：129101-54-8
| 产品名称: | Rivastigmine tartrate |
| CAS No.: | 129101-54-8 |
| Chemical Name: | N-ethyl-N-methyl-carbamic acid, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester, 2R,3R-dihydroxybutanedioate |
| Synonyms: | 酒石酸卡巴拉汀; ENA 713; SDZ-ENA 713 |
| 分子量: | 400.42 |
| 分子式: | C₁₈H₂₈N₂O₈ |
| SMILES: | O=C(OC1=CC=CC([C@@H](N(C)C)C)=C1)N(CC)C.O=C(O)[C@H](O)[C@@H](O)C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rivastigmine tartrate (ENA 713; SDZ-ENA 713) 是一种具有口服活性的，有效的胆碱酯酶 (ChE) 抑制剂，可抑制丁酰胆碱酯酶 (BChE) 和乙酰胆碱酯酶 (AChE)，IC50分别为 0.037 μM 和 4.15 μM。Rivastigmine tartrate 可透过血脑屏障 (BBB)。Rivastigmine tartrate 是一种拟副交感神经剂或胆碱能剂，用于研究轻度至中度阿尔茨海默氏型痴呆和帕金森氏病引起的痴呆。 |
| IC50和靶点: | |
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Yu, Q.S., Zhu, X., Holloway, H.W., et al.Anticholinesterase activity of compounds related to geneserine tautomers. N-oxides and 1,2-oxazinesJ. Med. Chem.45(17),3684-3691(2002)
Bailey, J.A., Ray, B., Greig, N.H., et al.Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neuronsPLoS One6(7),e21954(2011)
Ismail, M.F., Elmeshad, A.N., and Salem, N.A.Potential therapeutic effect of nanobased formulation of rivastigmine on rat model of Alzheimer's diseaseInt. J. Nanomedicine8,393-406(2013)
Papp, M., Gruca, P., Lason-Tyburkiewicz, M., et al.Antidepressant, anxiolytic and procognitive effects of rivastigmine and donepezil in the chronic mild stress model in ratsPsychopharmacology (Berl)233(7),1235-1243(2016)
