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Galanthamine N-Oxide

Cat. No.:YN380273

  • CAS No. :134332-50-6

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Galanthamine N-Oxide
      CAS No.: 134332-50-6
      Chemical Name: (4aS,6R,8aS,11R)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 11-oxide
      Synonyms:
      分子量:303.35
      分子式:C₁₇H₂₁NO₄
      SMILES:O[C@H]1C=C[C@@]23CC[N@@+](C)([O-])CC4=CC=C(OC)C(O[C@@]3([H])C1)=C24
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Galanthamine N-Oxide 是一种生物碱,分离于Zephyranthes concolor的球茎中。Galanthamine N-Oxide 抑制电鳗乙酰胆碱酯酶 (AChE),EC50为 26.2 μM。Galanthamine N-Oxide 是TcAChE,hAChE 和 hBChE 酶活性位点中底物调节的显著抑制剂。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Kobayashi, S., Satoh, K., Numata, A., et al.Alkaloid N-oxides from Lycoris sanguineaPhytochem.30(2),675-677(1991)

      Mannens, G.S.J., Snel, C.A.W., Hendrickx, J., et al.The metabolism and excretion of galantamine in rats, dogs, and humansDrug Metab. Dispos.30(5),553-563(2002)

      Reyes-Chilpa, R., Berkov, S., Hernández-Ortega, S., et al.Acetylcholinesterase-inhibiting alkaloids from Zephyranthes concolorMolecules16(11),9520-9533(2011)

      Li, X., Yu, H.-Y., Wang, Z.-Y., et al.Neuroprotective compounds from the bulbs of Lycoris radiataFitoterapia88,82-90(2013)

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