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(R)-Rivastigmine D6 tartrate

Cat. No.:YN380040

  • CAS No. :194930-00-2

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    • 参考文献
    • 产品名称: (R)-Rivastigmine D6 tartrate
      CAS No.: 194930-00-2
      Chemical Name: (S)-ethylmethyl-carbamic acid, 3-[1-[di(methyl-d3)amino]ethyl]phenyl ester, 2R,3R-dihydroxybutanedioate
      Synonyms:酒石酸卡巴拉汀 D6
      分子量:406.46
      分子式:C₁₈H₂₂D₆N₂O₈
      SMILES:O=C(OC1=CC=CC([C@@H](C)N(C([2H])([2H])[2H])C([2H])([2H])[2H])=C1)N(CC)C.O=C(O)[C@H](O)[C@@H](O)C(O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: (R)-Rivastigmine D6 tartrate 是 (R)-Rivastigmine 氘代化合物。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Yu, Q.S., Zhu, X., Holloway, H.W., et al.Anticholinesterase activity of compounds related to geneserine tautomers. N-oxides and 1,2-oxazinesJ. Med. Chem.45(17),3684-3691(2002)

      Bailey, J.A., Ray, B., Greig, N.H., et al.Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neuronsPLoS One6(7),e21954(2011)

      Ismail, M.F., Elmeshad, A.N., and Salem, N.A.Potential therapeutic effect of nanobased formulation of rivastigmine on rat model of Alzheimer's diseaseInt. J. Nanomedicine8,393-406(2013)

      Papp, M., Gruca, P., Lason-Tyburkiewicz, M., et al.Antidepressant, anxiolytic and procognitive effects of rivastigmine and donepezil in the chronic mild stress model in ratsPsychopharmacology (Berl)233(7),1235-1243(2016)

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