Pralidoxime chloride
Cat. No.：YN380197
| 产品名称: | Pralidoxime chloride |
| CAS No.: | 51-15-0 |
| Chemical Name: | 2-[(hydroxyimino)methyl]-1-methyl-pyridinium, monochloride |
| Synonyms: | 2-PAM chloride |
| 分子量: | 172.61 |
| 分子式: | C₇H₉ClN₂O |
| SMILES: | C[N+]1=CC=CC=C1/C=N/O.[Cl-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pralidoxime chloride属于肟类化合物, 可用于有机磷中毒的研究,对中毒乙酰胆碱酯酶具有恢复作用。 |
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Jokanović, M., and Stojiljković, M.P.Current understanding of the application of pyridinium oximes as cholinesterase reactivators in treatment of organophosphate poisoningEur. J. Pharmacol.553(1-3),10-17(2006)
Petroianu, G.A., Arafat, K., Kuca, K., et al.Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: In vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxonJ. Appl. Toxicol.26(1),64-71(2006)
Lorke, D.E., Hasan, M.Y., Arafat, K., et al.In vitro oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl-fluorophosphateJ. Appl. Toxicol.28(4),422-429(2008)
Costa, M.D., Freitas, M.L., Soares, F.A., et al.Potential of two new oximes in reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by organophosphate compounds: An in vitro studyToxicol. In Vitro25(8),2120-2123(2011)
Karade, H.N., Raviraju, G., Acharya, B.N., et al.Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE)Bioorg. Med. Chem.24(18),4171-4176(2016)
