Dasatinib hydrochloride
Cat. No.：YN440046
CAS No. ：854001-07-3
规格
价格(RMB)
库存
| 产品名称: | Dasatinib hydrochloride |
| CAS No.: | 854001-07-3 |
| Chemical Name: | |
| Synonyms: | 达沙替尼盐酸盐; BMS-354825 hydrochloride |
| 分子量: | 524.47 |
| 分子式: | C₂₂H₂₇Cl₂N₇O₂S |
| SMILES: | O=C(C1=CN=C(S1)NC2=NC(C)=NC(N3CCN(CC3)CCO)=C2)NC4=C(C=CC=C4Cl)C.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dasatinib hydrochloride (BMS-354825 hydrochloride) 是一种具有口服活性的，ATP 竞争性的Src/Bcr-Abl双重抑制剂，对 Src 和 Bcr-Abl 作用的Ki值分别为 16 pM 和 30 pM。Dasatinib hydrochloride 具有有效的抗肿瘤活性。 |
| IC50和靶点: | [{name:"Bcr-Abl:1.0 nM (IC50)"},{name: "Src:0.5 nM (IC50)"},{name: "lck:0.4 nM (IC50)"},{name: "Yes:0.5 nM (IC50)"},{name: "c-kit:5.0 nM (IC50)"},{name: "PDGFRβ:28 nM (IC50)"},{name: "p38:100 nM (IC50)"},{name: "Her1:180 nM (IC50)"},{name: "Her2:710 nM (IC50)"},{name: "FGFR-1:880 nM (IC50)"},{name: "MEK:1700 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
