Alectinib
Cat. No.：YN440237
CAS No. ：1256580-46-7
规格
价格(RMB)
库存
| 产品名称: | Alectinib |
| CAS No.: | 1256580-46-7 |
| Chemical Name: | 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile |
| Synonyms: | 艾乐替尼; CH5424802; RO5424802; AF802 |
| 分子量: | 482.62 |
| 分子式: | C₃₀H₃₄N₄O₂ |
| SMILES: | N#CC1=CC2=C(C3=C(N2)C(C)(C4=CC(N5CCC(CC5)N6CCOCC6)=C(C=C4C3=O)CC)C)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Alectinib (CH5424802) 是一种有效、选择性、具有口服活性的ALK抑制剂，其IC50为 1.9 nM，Kd值为 2.4 nM (以 ATP 竞争方式)，并且还抑制ALK F1174L和ALK R1275Q，其IC50分别为 1 nM 和 3.5 nM。Alectinib 还具有有效的中枢神经系统 (CNS) 渗透能力。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Sakamoto, H., Tskaguchi, T., Hiroshima, S., et al.CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutantCancer Cell19,679-690(2011)
Awad, M.M., and Shaw, A.T.ALK inhibitors in non-small cell lung cancer: Crizotinib and beyondClin. Adv. Hematol. Oncol.12(7),429-439(2014)
