PD 123319 ditrifluoroacetate
Cat. No.：YN320222
CAS No. ：136676-91-0
| 产品名称: | PD 123319 ditrifluoroacetate |
| CAS No.: | 136676-91-0 |
| Chemical Name: | (6S)-1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid, di(2,2,2-trifluoroacetate) |
| Synonyms: | PD123319; PD-123319; S-+-PD 123319 |
| 分子量: | 736.66 |
| 分子式: | C₃₅H₃₄F₆N₄O₇ |
| SMILES: | FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.O=C([C@@H]1CC2=C(N=CN2CC3=CC=C(N(C)C)C(C)=C3)CN1C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD 123319 ditrifluoroacetate 是一种有效的，选择性的AT2 angiotensin II receptor拮抗剂，IC50值为 34 nM。 |
| IC50和靶点: | |
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Bosnyak, S., Jones, E.S., Christopoulos, A., et al.Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptorsClin. Sci. (Lond.)121(7),297-303(2011)
Wexler, R.R., Greenlee, W.J., Irvin, J.D., et al.Nonpeptide angiotensin II receptor antagonists: The next generation in antihypertensive therapyJ. Med. Chem.39(3),625-656(2014)
Makino, N., Sugano, M., Otsuka, S., et al.Molecular mechanism of angiotensin II type I and type II receptors in cardiac hypertrophy of spontaneously hypertensive ratsHypertension30(4),796-802(1997)
Daugherty, A., Rateri, D.L., Howatt, D.A., et al.PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanismPLoS One8(4),e61849(2013)
