Olodanrigan
Cat. No.：YN320688
CAS No. ：1316755-16-4
| 产品名称: | Olodanrigan |
| CAS No.: | 1316755-16-4 |
| Chemical Name: | (3S)-2-(2,2-diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid |
| Synonyms: | EMA401; PD-126055 |
| 分子量: | 507.58 |
| 分子式: | C₃₂H₂₉NO₅ |
| SMILES: | O=C([C@H]1N(C(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC4=C(C(OCC5=CC=CC=C5)=C(OC)C=C4)C1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Olodanrigan (EMA401) 是一个高选择性、口服活性、外周受限的血管紧张素 Ⅱ 类型 2 受体(AT2R)拮抗剂。可用于神经性疼痛的研究。Olodanrigan (EMA401) 的镇痛作用似乎包括抑制增强的 AngII/AT2R 诱导的 p38 和 p42/p44 MAPK 激活，从而抑制 DRG 神经元的过度兴奋性和 DRG 神经元的萌发。 |
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Smith, M.T., Wyse, B.D., and Edwards, S.R.Small molecule angiotensin II type 2 receptor (AT₂R) antagonists as novel analgesics for neuropathic pain: Comparative pharmacokinetics, radioligand binding, and efficacy in ratsPain Med.14(5),692-705(2013)
Anand, U., Facer, P., Yiangou, Y., et al.Angiotensin II type 2 receptor (AT2R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neuronsEur J. Pain.17(7),1012-1026(2012)
Hanyan, X., Benzhuo, Z., Liping, H., et al.Analgesic effect of angiotensin angiotensin Ⅱ type 2 receptor antagonist EMA401 on neuropathic pain in rats and its mechanismChin. J. Pathophysiol.33(1),110-115(2017)
