Angiotensin II human acetate
Cat. No.：YN320810
CAS No. ：68521-88-0
| 产品名称: | Angiotensin II human acetate |
| CAS No.: | 68521-88-0 |
| Chemical Name: | 5-L-isoleucine-angiotensin II, acetate |
| Synonyms: | Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate |
| 分子量: | 1106.23 |
| 分子式: | C₅₂H₇₅N₁₃O₁₄ |
| SMILES: | O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC=N2)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CC=CC=C4)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N.CC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Angiotensin II human acetate (Angiotensin II acetate) 是主要作用于AT1受体的血管收缩剂。Angiotensin II human acetate 刺激交感神经刺激，增加醛固酮的生物合成和肾功能。Angiotensin II human acetate 诱导血管平滑肌细胞的生长，增加成纤维细胞中 I 型和 III 型胶原的合成，导致血管壁和心肌增厚以及纤维化。Angiotensin II human acetate 还可诱导细胞凋亡 (apoptosi |
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Burnier, M.Angiotensin II type 1 receptor blockersCirculation103(6),904-912(2001)
Redelinghuys, P., Nchinda, A.T., and Sturrock, E.D.Development of domain-selective angiotensin I-converting enzyme inhibitorsAnn. N. Y. Acad. Sci.1056,160-175(2005)
Bosnyak, S., Jones, E.S., Christopoulos, A., et al.Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptorsClin. Sci. (Lond.)121(7),297-303(2011)
Wexler, R.R., Greenlee, W.J., Irvin, J.D., et al.Nonpeptide angiotensin II receptor antagonists: The next generation in antihypertensive therapyJ. Med. Chem.39(3),625-656(2014)
