AVE 0991
Cat. No.：YN321032
CAS No. ：304462-19-9
规格
价格(RMB)
库存
| 产品名称: | AVE 0991 |
| CAS No.: | 304462-19-9 |
| Chemical Name: | N-[(ethylamino)carbonyl]-3-[4-[(5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)-2-thiophenesulfonamide |
| Synonyms: | |
| 分子量: | 580.72 |
| 分子式: | C₂₉H₃₂N₄O₅S₂ |
| SMILES: | O=S(C1=C(C2=CC=C(CN3C(C=O)=C(OC)N=C3C4=CC=CC=C4)C=C2)C=C(CC(C)C)S1)(NC(NCC)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AVE 0991 是一种有效的非肽Ang-(1-7)受体 Mas 激动剂。AVE 0991 与 [125I]-Ang-(1-7) 竞争性地结合到牛主动脉内皮细胞膜，IC50为 21 nM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Pinheiro, S.V.B., Simões e Silva, A.C., Sampaio, W.O., et al.Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidneyHypertension44(4),490-496(2004)
Wiemer, G., Dobrucki, L.W., Louka, F.R., et al.AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endotheliumHypertension40(6),847-852(2002)
Skiba, D.S., Nosalski, R., Mikolajczyk, T.P., et al.Anti-atherosclerotic effect of the angiotensin 1-7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosisBr. J. Pharmacol.174(22),4055-4069(2017)
