Candesartan Cilexetil
Cat. No.：YN321155
CAS No. ：145040-37-5
| 产品名称: | Candesartan Cilexetil |
| CAS No.: | 145040-37-5 |
| Chemical Name: | 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester |
| Synonyms: | 坎地沙坦酯; TCV-116 |
| 分子量: | 610.66 |
| 分子式: | C₃₃H₃₄N₆O₆ |
| SMILES: | O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)=CC=C1)OC(OC(OC6CCCCC6)=O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Candesartan Cilexetil (TCV-116)是血管紧张素II拮抗剂，可用于高血压。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Shibouta, Y., Inada, Y., Ojima, M., et al.Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116)J. Pharmacol. Exp. Ther.266(1),114-120(1993)
Gavras, H.Update on the clinical pharmacology of candesartan cilexetilAm. J. Hypertens.13(1 Pt.2),25S-30S(2000)
Inada, Y., Wada, T., Shibouta, Y., et al.Antihypertensive effects of a highly potent and long-acting angiotensin II subtype-1 receptor antagonist, (+-)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H- benzimidazole-7-carboxylate (TCV-116), in various hypertensive ratsJ. Pharmacol. Exp. Ther.268(3),1540-1547(1993)
Inada, Y., Wade, T., Ojima, M., et al.Protective effects of candesartan cilexetil (TCV-116) against stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive ratsClin. Exp. Hypertens.19(7),1079-1099(1997)
Bregonzio, C., Seltzer, A., Armando, I., et al.Angiotensin II AT1 receptor blockade selectively enhances brain AT2 receptor expression, and abolishes the cold-restraint stress-induced increase in tyrosine hydroxylase mRNA in the locus coeruleus of spontaneously hypertensive ratsStress11(6),457-466(2008)
