Losartan D4
Cat. No.：YN321158
| 产品名称: | Losartan D4 |
| CAS No.: | 1030937-27-9 |
| Chemical Name: | 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl-2,3,5,6-d4]methyl]-1H-imidazole-5-methanol |
| Synonyms: | 氯沙坦 D4; DuP-753 D4 |
| 分子量: | 426.94 |
| 分子式: | C₂₂H₁₉D₄ClN₆O |
| SMILES: | OCC1=C(Cl)N=C(CCCC)N1CC2=C([2H])C([2H])=C(C3=CC=CC=C3C4=NNN=N4)C([2H])=C2[2H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Losartan D4 (DuP-753 D4) 是 Losartan 的氘代物。 |
| IC50和靶点: | |
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Ji, H., Leung, M., Zhang, Y., et al.Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartanJ. Biol. Chem.269(24),16533-16536(1994)
Ge, J., Huang, D., Liang, C., et al.Upregulation of lectinlike oxidized low-density lipoprotein receptor-1 expression contributes to the vein graft atherosclerosis: Modulation by losartanAtherosclerosis177(2),263-268(2004)
Xavier, F.E., Rossoni, L.V., Alonso, M.J., et al.Ouabain-induced hypertension alters the participation of enothelial factors in α-adrenergic responses differently in rat resistance and conductance mesenteric arteriesBr. J. Pharmacol.143(1),215-225(2004)
Caruso, D., D'Avino, M., Acampora, C., et al.Effects of losartan and chlorthalidone on blood pressure and renal vascular resistance index in non-diabetic patients with essential hypertension and normal renal functionsJ. Cardiovasc. Pharmacol.44(5),520-524(2004)
