Droxinostat
Cat. No.：YN270219
CAS No. ：99873-43-5
| 产品名称: | Droxinostat |
| CAS No.: | 99873-43-5 |
| Chemical Name: | 4-(4-chloro-2-methylphenoxy)-N-hydroxy-butanamide |
| Synonyms: | NS 41080 |
| 分子量: | 243.69 |
| 分子式: | C₁₁H₁₄ClNO₃ |
| SMILES: | ClC1=CC=C(C(C)=C1)OCCCC(NO)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Droxinostat(NS41080)是HDAC3，HDAC6和HDAC8抑制剂，IC50分别为16.9，2.47和1.46 μM。 |
| IC50和靶点: | [{name:"HDAC8:1.46 μM (IC50)"},{name: "HDAC6:2.47 μM (IC50)"},{name: "HDAC3:16.9 μM (IC50)"}] |
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Wood, T.E., Dalili, S., Simpson, C.D., et al.Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligandsMol. Cancer Ther.9(1),246-256(2010)
Liu, J., Li, G., Wang, X., et al.Droxinostat, a histone deacetylase inhibitor, induces apoptosis in hepatocellular carcinoma cell lines via activation of the mitochondrial pathway and downregulation of FLIPTransl. Oncol.9(1),70-78(2016)
