Phenoxodiol
Cat. No.：YN270262
CAS No. ：81267-65-4
| 产品名称: | Phenoxodiol |
| CAS No.: | 81267-65-4 |
| Chemical Name: | 3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol |
| Synonyms: | Idronoxil; Dehydroequol; Haginin E |
| 分子量: | 240.25 |
| 分子式: | C₁₅H₁₂O₃ |
| SMILES: | OC1=CC=C2C=C(C3=CC=C(O)C=C3)COC2=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Phenoxodiol是一种合成genestein的类似物，激活线粒体caspase系统，抑制XIAP(一个凋亡抑制剂)，使癌细胞对fas介导的凋亡敏感。Phenoxodiol还通过稳定可分裂复合物抑制DNA拓扑异构酶II，从而阻止DNA复制。Phenoxodiol 在细胞周期的G1/S期诱导细胞周期阻滞，通过独立于p53的方式上调p21WAF1。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Rahmani, R., Bouajila, J., Jouaidi, M., et al.African mustard (Brassica tournefortii) as source of nutrients and nutraceuticals propertiesJ. Food Sci.85(6),1856-1871(2020)
Kamsteeg, M., Rutherford, T., Sapi, E., et al.Phenoxodiol – an isoflavone analog – induces apoptosis in chemoresistant ovarian cancer cellsOncogene22(17),2611-2620(2003)
Constantinou, A.I., Mehta, R., and Husband, A.Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague–Dawley ratsEur. J. Cancer39(7),1012-1018(2004)
