Becatecarin
Cat. No.：YN290586
| 产品名称: | Becatecarin |
| CAS No.: | 119673-08-4 |
| Chemical Name: | 1,11-dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-b-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione |
| Synonyms: | NSC 655649; BMS 181176; BMY 27557 |
| 分子量: | 669.6 |
| 分子式: | C33H34Cl2N4O7 |
| SMILES: | O=C(N(CCN(CC)CC)C1=O)C2=C1C(C(C=CC=C3Cl)=C3N4[C@@H]5O[C@H](CO)[C@@H](OC)[C@H](O)[C@H]5O)=C4C6=C2C7=C(C(Cl)=CC=C7)N6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Becatcarin是一种rebeccamycin类似物，具有抗肿瘤作用。Becatecarin插入DNA并抑制拓扑异构酶I/II的催化活性。 |
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Kaneko, T., Wong, H., Utzig, J., et al.Water soluble derivatives of rebeccamycinJ. Antibiot. (Tokyo)43(1),125-127(1990)
Long, B.H., Rose, W.C., Vyas, D.M., et al.Discovery of antitumor indolocarbazoles: Rebeccamycin, NSC 655649, and fluoroindolocarbazolesCurr. Med. Chem. Anticancer Agents2(2),255-266(2002)
Ricart, A.D., Hammond, L.A., Kuhn, J.G., et al.Phase I and pharmacokinetic study of sequences of the rebeccamycin analogue NSC 655649 and cisplatin in patients with advanced solid tumorsClin. Cancer Res.11(24 Pt 1),8728-8736(2005)
Schwandt, A., Mekhail, T., Halmos, B., et al.Brief report: Phase II trial of rebeccamycin analogue, a dual topoisomerase I and II inhibitor, in relapsed "sensitive" small cell lung cancerJ. Thorac. Oncol.7(1),751-754(2012)
Robey, R.W., Obrzut, T., Shukla, S., et al.Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cellsCancer Chemother. Pharmacol.64(3),575-583(2009)
