DPQ
Cat. No.：YN290599
CAS No. ：129075-73-6
| 产品名称: | DPQ |
| CAS No.: | 129075-73-6 |
| Chemical Name: | 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone |
| Synonyms: | |
| 分子量: | 302.4 |
| 分子式: | C18H26N2O2 |
| SMILES: | O=C1NCCC2=C(OCCCCN3CCCCC3)C=CC=C21 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DPQ 是一种有效的PARP-1抑制剂。DPQ可降低 N- 甲基 -D- 天冬氨酸 (NMDA) 诱导的PARP激活，使 ATP 恢复到接近正常水平，且在 NMDA 严重暴露模型中显著减轻神经元损伤。DPQ 可用于神经保护研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Davar, D., Beumer, J.H., Hamieh, L., et al.Role of PARP inhibitors in cancer biology and therapyCurr. Med. Chem.19(23),3907-3921(2012)
Mathews, M.T., and Berk, B.C.PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2Arterioscler. Thromb. Vasc. Biol.28,711-717(2008)
Costantino, G., Macchiarulo, A., Camaioni, E., et al.Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationships analysisJ. Med. Chem.44,3786-3794(2001)
Eltze, T., Boer, R., Wagner, T., et al.Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): A comparison with standard PARP inhibitorsMol. Pharmacol.74(6),1587-1598(2008)
Fonfria, E., Marshall, I.C.B., Benham, C.D., et al.TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymeraseBr. J. Pharmacol.143,186-192(2004)
Giovannelli, L., Cozzi, A., Guarnieri, I., et al.Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: Differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitorsJ. Cereb. Blood Flow Metab.22(6),697-704(2002)
