Cudraflavone B
Cat. No.：YN290748
| 产品名称: | Cudraflavone B |
| CAS No.: | 304896-21-7 |
| Chemical Name: | 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-8-quinolinyl-2-propenamide |
| Synonyms: | SIRT2 Inhibitor,Inactive Control |
| 分子量: | 434.3 |
| 分子式: | C23H13Cl2N3O2 |
| SMILES: | O=C(/C(C#N)=C/C1=CC=C(C2=CC(Cl)=CC=C2Cl)O1)NC3=CC=CC4=C3N=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AGK7 是一种有效的sirtuin2 (SIRT2) 抑制剂。AGK7 拯救了帕金森病细胞模型中的 α-突触核蛋白毒性和修饰的包涵体形态。AGK7 在体外和帕金森病果蝇模型中均能防止多巴胺能细胞死亡。 |
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Outeiro, T.F., Kontopoulos, E., Altmann, S.M., et al.Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's diseaseScience317(5837),516-519(2007)
Cole, P.A.Chemical probes for histone-modifying enzymesNat. Chem. Biol.4(10),590-597(2008)
