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PR-619

Cat. No.：2645-32-1

  • CAS No. ：2645-32-1

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    • 产品名称: PR-619
      CAS No.: 2645-32-1
      Chemical Name:
      Synonyms:PR 619,2,6-Diamino-3,5-dithiocyanopyridine
      分子量:223.28
      分子式:C₇H₅N₅S₂
      SMILES:NC1=C(SC#N)C=C(SC#N)C(N)=N1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Altun, M., Kramer, H.B., Willems, L.I., et al.Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymesChem. Biol.18(11),1401-1412(2011)', 'Udeshi, N.D., Mani, D.R., Eisenhaure, T., et al.Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibitionMol. Cell. Proteomics11(15),148-159(2012)', 'Balut, C.M., Loch, C.M., and Devor, D.C.Role of ubiquitylation and USP8-dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1FASEB J.25(11),3938-3948(2011)', 'Seiberlich, V., Goldbaum, O., Zhukareva, V., et al.The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: Implications for neurodegenerative diseasesBiochim. Biophys. Acta1823(11),2057-2068(2012)', 'Bertuccio, C.A., Lee, S.L., Wu, G., et al.Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1- and Rab8-dependent and recycling endosome-independentPLoS One9(3),1-16(2014)
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