GLPG1837
Cat. No.：YN360258
CAS No. ：1654725-02-6
| 产品名称: | GLPG1837 |
| CAS No.: | 1654725-02-6 |
| Chemical Name: | N-[3-(aminocarbonyl)-4,7-dihydro-5,5,7,7-tetramethyl-5H-thieno[2,3-c]pyran-2-yl]-1H-pyrazole-3-carboxamide |
| Synonyms: | ABBV-974 |
| 分子量: | 348.42 |
| 分子式: | C₁₆H₂₀N₄O₃S |
| SMILES: | O=C(C1=NNC=C1)NC(S2)=C(C(N)=O)C3=C2C(C)(C)OC(C)(C)C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GLPG1837 是一种有效的，可逆的CFTR增强剂，对 CFTR 的 突变体 F508del 和 G551D 的EC50值分别为 3 nM 和 339 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Gees, M., Musch, S., Van der Plas, S., et al.Identification and characterization of novel CFTR potentiatorsFront. Pharmacol.9,(2018)
Van der Plas, S., Kelgtermans, H., De Munck, T., et al.Discovery of N‑(3-carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro‑4H‑thieno[2,3‑c]pyran-2-yl)‑lH‑pyrazole-5-carboxamide (GLPG1837), a novel potentiator which can open class III mutant cystic fibrosis transmembrane conductance regulator (CFTR) channels to a high extentJ. Med. Chem.61(4),1425-1435(2018)
