Meglutol
Cat. No.：YN372891
CAS No. ：503-49-1
规格
价格(RMB)
库存
| 产品名称: | Meglutol |
| CAS No.: | 503-49-1 |
| Chemical Name: | 3-hydroxy-3-methyl-pentanedioic acid |
| Synonyms: | Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid |
| 分子量: | 162.14 |
| 分子式: | C₆H₁₀O₅ |
| SMILES: | O=C(O)CC(C)(O)CC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Meglutol是一种抗血脂剂, 降低胆固醇, 甘油三酯, 及血清β-脂蛋白和磷脂, 并抑制羟甲基戊二酰辅酶A还原酶活性, 这是在胆固醇生物合成中的限速酶。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Medina-Franco, J.L., López-Vallejo, F., Rodríguez-Morales, S., et al.Molecular docking of the highly hypolipidemic agent α-asarone with the catalytic portion of HMG-CoA reductaseBioorg. Med. Chem. Lett.15(4),989-994(2005)
Beg, Z.H., and Siddiqi, M.Hypocholesterolemic effect of 3-hydroxy-3-methylglutaric acidExperientia23(5),380(1967)
Lupien, P.J., Tremblay, M., and Beg, Z.H.3-Hydroxy-3-methylglutaric acid: Protective action in experimental atherosclerosis in rabbitsAtherosclerosis18(3),407-416(1973)
da Rosa, M.S., da Rosa-Junior, N.T., Parmeggiani, B., et al.3-Hydroxy-3-methylglutaric acid impairs redox and energy homeostasis, mitochondrial dynamics, and endoplasmic reticulum-mitochondria crosstalk in rat brainNeurotox. Res.37(2),314-325(2020)
