L-685458
Cat. No.：YN380134
CAS No. ：292632-98-5
规格
价格(RMB)
库存
| 产品名称: | L-685458 |
| CAS No.: | 292632-98-5 |
| Chemical Name: | N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-L-phenylalaninamide |
| Synonyms: | L-685,458 |
| 分子量: | 672.85 |
| 分子式: | C₃₉H₅₂N₄O₆ |
| SMILES: | O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)C[C@@H](O)[C@@H](NC(OC(C)(C)C)=O)CC3=CC=CC=C3)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L-685458是一种有效的淀粉样β蛋白前体γ分泌酶抑制剂, IC50为17 nM,比作用于其他天冬氨酰蛋白酶选择性高50-100倍。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Shearman, M.S., Beher, D., Clarke, E.E., et al.L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid β-protein precursor γ-secretase activityBiochemistry39(30),8698-8704(2000)
Hiyama, A., Skubutyte, R., Markova, D., et al.Hypoxia activated the Notch signaling pathway in cells of the intervertebral disc: Implications in degenerative disc diseaseArthritis Rheum.63(5),1355-1364(2011)
