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Lorglumide sodium salt

Cat. No.:YN321656

  • CAS No. :1021868-76-7

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    • 产品名称: Lorglumide sodium salt
      CAS No.: 1021868-76-7
      Chemical Name: 4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoic acid, monosodium salt
      Synonyms:CR-1409 sodium salt
      分子量:481.39
      分子式:C₂₂H₃₁Cl₂N₂NaO₄
      SMILES:ClC1=C(C=CC(C(NC(CCC(O[Na])=O)C(N(CCCCC)CCCCC)=O)=O)=C1)Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Lorglumide sodium salt (CR-1409 sodium salt) 是一种有效的胆囊收缩素(CCK)受体拮抗剂。
      IC50和靶点:
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      In Vivo:
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    • Sabbatini, M.E., Chen, X., Ernst, S.A., et al.Rap1 activation plays a regulatory role in pancreatic amylase secretionJ. Biol. Chem.,(2008)

      Murphy, K.G., and Bloom, S.R.Gut hormones in the control of appetiteExp. Physiol.89(5),507-516(2004)

      Wynne, K., Stanley, S., and Bloom, S.The gut and regulation of body weightJ. Clin. Endocrinol. Metab.89(6),2576-2582(2004)

      Makovec, F., Peris, W., Revel, L., et al.Structure-antigastrin activity relationships of new (R)-4-benzamido-5-oxopentanoic acid derivativesJ. Med. Chem.35(1),28-38(1992)

      Barthó, L., Holzer, P., Lembeck, F., et al.Evaluation of a new and potent cholecystokinin antagonist on motor responses of the guinea-pig intestineBr. J. Pharmacol.90,753-761(1987)

      Niederau, C., Liddle, R.A., Williams, J.A., et al.Pancreatic growth: Interaction of exogenous cholecystokinin, a protease inhibitor, and a cholecystokinin receptor antagonist in miceGut28,63-69(1987)

      Scarpignato, C., Varga, G., Dobronyi, I., et al.Effect of a new potent CCK antagonist, lorglumide, on caerulein- and bombesin-induced pancreatic secretion and growth in the ratBr. J. Pharmacol.96,661-669(1989)

      Gamble, J., Kenny, S., and Dockray, G.J.Plasminogen activator inhibitor (PAI)-1 suppresses inhibition of gastric emptying by cholecystokinin (CCK) in miceRegul. Pept.185,9-13(2013)

      Lo, C.C., Davidson, W.S., Hibbard, S.K., et al.Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male ratsEndocrinology155(5),1700-1707(2014)

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