RG108
Cat. No.：YN310233
CAS No. ：48208-26-0
| 产品名称: | RG108 |
| CAS No.: | 48208-26-0 |
| Chemical Name: | αS-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1H-indole-3-propanoic acid |
| Synonyms: | N-Phthalyl-L-tryptophan |
| 分子量: | 334.33 |
| 分子式: | C₁₉H₁₄N₂O₄ |
| SMILES: | O=C(N1[C@H](C(O)=O)CC2=CNC3=C2C=CC=C3)C4=CC=CC=C4C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RG108 (N-Phthalyl-L-tryptophan) 是一种非核苷的 DNA 甲基转移酶 (DNMTs) 抑制剂 (IC50=115 nM)，RG108 (N-Phthalyl-L-tryptophan) 阻断 DNA 甲基转移酶的活性位点。RG108 (N-Phthalyl-L-tryptophan) 引起抑癌基因的去甲基化和再激活，但不影响着丝粒卫星序列的甲基化。 |
| IC50和靶点: | [{name:"CpG methylase M.SssI:115 nM (IC50)"}] |
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| Solvent & Solubility: |
Brueckner, B., Boy, R.G., Siedlecki, P., et al.Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferasesCancer Res.65(14),6305-6311(2005)
Stresemann, C., Brueckner, B., Musch, T., et al.Functional diversity of DNA methyltransferase inhibitors in human cancer cell linesCancer Res.66(5),2794-2800(2006)
