7α,25-Dihydroxycholesterol
Cat. No.：YN320469
| 产品名称: | 7α,25-Dihydroxycholesterol |
| CAS No.: | 64907-22-8 |
| Chemical Name: | (3β,7α)-cholest-5-ene-3,7,25-triol |
| Synonyms: | 7α,25-OHC |
| 分子量: | 418.65 |
| 分子式: | C₂₇H₄₆O₃ |
| SMILES: | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])[C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=C[C@H]3O)C)([H])CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 7α, 25-dihydroxycholesterol (7α,25-OHC) 是一种孤儿 GPCR 受体EBI2 (GPR183)的有效选择性激动剂和内源性配体。7α, 25-dihydroxycholesterol 对激活 EBI2 有很强的作用 (EC50=140 pM;Kd=450 pM)。7α, 25-dihydroxycholesterol 可作为一种趋化因子，指导 B 细胞、T 细胞和树突状细胞的迁移。 |
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Liu, C., Yang, X.V., Wu, J., et al.Oxysterols direct B-cell migration through EB12Nature475(7357),519-523(2011)
Hannedouche, S., Zhang, J., Yi, T., et al.Oxysterols direct immune cell migration via EBI2Nature475(7357),524-527(2011)
