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> 产品中心 > 抑制剂 & 激动剂 > Metabolic Enzyme/Protease > Epoxide Hydrolase

trans-AUCB

Cat. No.:YN370785

  • CAS No. :885012-33-9

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    • 参考文献
    • 产品名称: trans-AUCB
      CAS No.: 885012-33-9
      Chemical Name: 4-[[trans-4-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]cyclohexyl]oxy]-benzoic acid
      Synonyms:t-AUCB
      分子量:412.52
      分子式:C₂₄H₃₂N₂O₄
      SMILES:OC(C(C=C1)=CC=C1O[C@@H](CC2)CC[C@H]2NC(NC34C[C@H](C5)C[C@H](C[C@H]5C4)C3)=O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: trans-AUCB (t-AUCB) 是一种有效的,具有口服活性和选择性的可溶性环氧水解酶 (sEH) 抑制剂,对 人,小鼠和大鼠的 sEH 的IC50分别为 1.3 nM,8 nM,8 nM。trans-AUCB 具有抗神经胶质瘤活性。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Schmelzer, K.R., Kubala, L., Newman, J.W., et al.Soluble epoxide hydrolase is a therapeutic target for acute inflammationProc. Natl. Acad. Sci. USA102(28),9772-9777(2005)

      Yu, Z., Xu, F., Huse, L.M., et al.Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acidsCirc. Res.87(11),992-998(2000)

      Hwang, S.H., Wagner, K.M., Morisseau, C., et al.Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolaseJ. Med. Chem.54(8),3037-3050(2011)

      Tsai, H.J., Hwang, S.H., Morisseau, C., et al.Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogsEur. J. Pharm. Sci.40(3),222-238(2010)

      Imig, J.D., and Hammock, B.D.Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseasesNat. Rev. Drug Discov.8(10),794-805(2009)

      Zhang, G., Panigrahy, D., Hwang, S.H., et al.Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasisProc. Natl. Acad. Sci. USA111(30),11127-11132(2014)

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