Falnidamol
Cat. No.：YN340039
| 产品名称: | Falnidamol |
| CAS No.: | 196612-93-8 |
| Chemical Name: | N8-(3-chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diamine |
| Synonyms: | BIBX 1382 |
| 分子量: | 387.84 |
| 分子式: | C₁₈H₁₉ClFN₇ |
| SMILES: | ClC1=CC(NC2=NC=NC3=CN=C(NC(CC4)CCN4C)N=C23)=CC=C1F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Falnidamol (BIBX 1382) 是一种具有口服活性的，选择性的EGFR 酪氨酸激酶抑制剂，IC50为3 nM。Falnidamol 对 ErbB2 (IC50=3.4 μM) 和其他一系列相关酪氨酸激酶 (IC50>10 μM) 的选择性 >1000倍。Falnidamol 是嘧啶-嘧啶化合物，具有抗癌活性。 |
| IC50和靶点: | [{name:"EGFR:3 nM (IC50)"},{name: "ErbB2:3.4 μM (IC50)"}] |
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Solca, F.F., Baum, A., Langkopf, E., et al.Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivativesJ. Pharmacol. Exp. Ther.311(2),502-509(2004)
Toulany, M., Dittmann, K., Baumann, M., et al.Radiosensitization of ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BSRadiother. Oncol.74(2),117-129(2005)
