3-Hydroxy Midostaurin
Cat. No.：YN440110
CAS No. ：179237-49-1
规格
价格(RMB)
库存
| 产品名称: | 3-Hydroxy Midostaurin |
| CAS No.: | 179237-49-1 |
| Chemical Name: | N-(2,3,10,11,12,13-Hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide; CGP 52421 |
| Synonyms: | CGP52421 |
| 分子量: | 586.64 |
| 分子式: | C₃₅H₃₀N₄O₅ |
| SMILES: | OC1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(O[C@@H](N7C5=C2C8=C7C=CC=C8)C[C@H]([C@H]6OC)N(C(C9=CC=CC=C9)=O)C)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 3-Hydroxy Midostaurin (CGP 52421) 是 PKC412 的代谢产物，可有效抑制 FMS 样酪氨酸激酶 3 (FLT3) 自磷酸化，在培养基和血浆中的IC50分别为 132 nM 和 9.8 μM。与 PKC412 相比，3-Hydroxy Midostaurin 的选择性较低，但细胞毒性更高。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012)
Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012)
