MRX-2843
Cat. No.：YN440035
CAS No. ：1429882-07-4
规格
价格(RMB)
库存
| 产品名称: | MRX-2843 |
| CAS No.: | 1429882-07-4 |
| Chemical Name: | trans-4-[2-[(2-cyclopropylethyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol |
| Synonyms: | UNC2371 |
| 分子量: | 488.67 |
| 分子式: | C₂₉H₄₀N₆O |
| SMILES: | O[C@H]1CC[C@H](N2C=C(C3=CC=C(CN4CCN(C)CC4)C=C3)C5=CN=C(NCCC6CC6)N=C52)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MRX-2843 (UNC2371) 是一种具有口服活性的MERTK和FLT3酪氨酸激酶抑制剂 (TKI)，IC50分别为 1.3 nM 和 0.64 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Zhang, W., DeRychere, D., Hunter, D., et al.UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitorJ. Med. Chem.57(16),7031-7041(2014)
Minson, K.A., Smith, C.C., DeRyckere, D., et al.The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemiaJCI Insight1(3),e85630(2016)
